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. Author manuscript; available in PMC: 2018 Jul 23.
Published in final edited form as: Biometrics. 2017 Jul 6;74(1):49–57. doi: 10.1111/biom.12738

Table 1.

Redesigning the Sepsicool trial. Results from 5000 replications for different CARA procedures, N = 450

Alternative
Procedure b (1 − β) N0(N)/N (s.d) N0t* (N)/N (s.d) N1t* (N)/N (s.d) ENF (s.d) p* (s.d) CM
ER 1 0.91 0.500 (0.02) 0.500 (0.03) 0.500 (0.04) 119.22 (9.24) 0.500 (0.02)   0.0
SPBD 10 0.90 0.500 (0.02) 0.500 (0.02) 0.500 (0.02) 119.14 (9.39) 0.500 (0.02)   0.0
CARA 1 10 0.88 0.330 (0.06) 0.697 (0.09) 0.626 (0.09) 106.94 (10.23) 0.662 (0.07)   1.5
CARA 2 10 0.91 0.476 (0.03) 0.528 (0.04) 0.520 (0.04) 117.54 (9.36) 0.524 (0.03)   0.0
CARA 3 10 0.91 0.453 (0.03) 0.560 (0.04) 0.532 (0.04) 115.81 (9.50) 0.547 (0.03)   0.0
CARA 4 10 0.89 0.391 (0.04) 0.638 (0.06) 0.578 (0.06) 111.02 (9.91) 0.609 (0.04)   0.0
TS 10 0.89 0.301 (0.06) 0.737 (0.08) 0.660 (0.09) 104.68 (9.42) 0.699 (0.06)   6.2
CARA FLGI 50 0.44 0.142 (0.09) 0.810 (0.19) 0.904 (0.07)   92.30 (9.53) 0.858 (0.09) 38.0
CARA FLGI 45 0.38 0.123 (0.10) 0.896 (0.15) 0.856 (0.16)   91.90 (10.71) 0.877 (0.10) 28.0
CARA FLGI 30 0.42 0.108 (0.09) 0.851 (0.19) 0.931 (0.05)   90.30 (10.13) 0.892 (0.09) 30.0
CARA FLGI 10 0.20 0.133 (0.17) 0.902 (0.23) 0.830 (0.27)   90.94 (13.96) 0.867 (0.17) 18.0
CARA GI 1 0.18 0.102 (0.14) 0.930 (0.16) 0.864 (0.25)   91.54 (12.84) 0.898 (0.14) 14.0
Null
Procedure b α N0(N)/N (s.d) N0t* (N)/N (s.d) N1t* (N)/N (s.d) ENF (s.d) p* (s.d) CM
ER 1 0.05 0.500 (0.02) 0.500 (0.03) 0.500 (0.03) 154.33 (9.95) 0.500 (0.02) 0.0
SPBD 10 0.05 0.500 (0.02) 0.501 (0.02) 0.500 (0.02) 154.58 (9.95) 0.500 (0.02) 0.0
CARA 1 10 0.05 0.500 (0.06) 0.500 (0.09) 0.500 (0.09) 154.44 (10.22) 0.500 (0.06) 0.0
CARA 2 10 0.05 0.500 (0.03) 0.500 (0.04) 0.500 (0.04) 154.28 (10.03) 0.500 (0.03) 0.0
CARA 3 10 0.05 0.500 (0.02) 0.500 (0.03) 0.499 (0.04) 154.53 (10.13) 0.499 (0.03) 0.0
CARA 4 10 0.05 0.500 (0.04) 0.500 (0.05) 0.499 (0.05) 154.41 (10.05) 0.499 (0.04) 0.0
TS 10 0.06 0.501 (0.07) 0.501 (0.10) 0.501 (0.10) 154.61 (10.14) 0.501 (0.07) 0.0
CARA FLGI 50 0.06 0.555 (0.28) 0.523 (0.24) 0.490 (0.33) 155.76 (11.23) 0.522 (0.24) 4.0
CARA FLGI 45 0.04 0.533 (0.23) 0.522 (0.34) 0.544 (0.29) 155.42 (10.22) 0.533 (0.23) 4.0
CARA FLGI 30 0.04 0.481 (0.35) 0.535 (0.27) 0.586 (0.38) 154.22 (10.10) 0.535 (0.27) 2.0
CARA FLGI 10 0.04 0.467 (0.31) 0.463 (0.42) 0.472 (0.39) 152.52 (9.44) 0.467 (0.31) 4.0
CARA GI 1 0.06 0.512 (0.29) 0.555 (0.40) 0.467 (0.42) 154.78 (10.28) 0.512 (0.29) 2.0