Table 1. Characteristics of 87 transplant patients with toxoplasmosis, according to clinical presentation, Europe, 2010–2014*.
| Variables |
Clinical type | p value |
|||||
|---|---|---|---|---|---|---|---|
| Cerebral |
Ocular |
Disseminated |
Pulmonary |
Fever alone |
No signs |
||
| No. (%) patients |
13 (15) |
4 (5) |
19 (22) |
10 (11) |
10 (11) |
31 (36) |
|
| Patient age, y, mean ± SE |
37.0 ± 7.7 |
60.7 ± 0.8 |
47.8 ± 5.6 |
53.1 ± 4.8 |
35.5 ±4.4 |
46.4 ± 4.2 |
<0.0001 |
| Time graft/diagnosis, wk, mean ± SE |
123 ± 151 |
313 ± 175 |
163 ± 124 |
19 ± 11 |
73 ± 43 |
99 ± 51 |
<0.05 |
| Diagnosis by, no. (%) |
|
|
|
|
|
|
|
| PCR | 13 (100) | 3 (75) | 17 (89) | 9 (90) | 9 (90) | 26 (84) | <0.001 |
| Serology | 3 (23) | 3 (75) | 9 (47) | 2 (20) | 5 (50) | 5 (16) | 0.2278 |
| Imaging | 12 (92) | 3 (75) | 8 (42) | 7 (70) | 0 | 2 (6) | <0.01 |
| Microscopy |
1 (8) |
0 |
6 (32) |
1 (10) |
0 |
0 |
<0.01 |
| Graft type, no. (%) | <0.05 | ||||||
| Liver, n = 8 | 1 (8) | 1 (25) | 3 (16) | 2 (20) | 0 | 1 (3) | |
| Kidney, n = 9 | 1 (8) | 1 (25) | 1 (5) | 2 (20) | 3 (30) | 1 (3)† | |
| Heart, n = 12 | 0 | 1 (25) | 5 (26) | 0 | 2 (20) | 4 (13)‡ | |
| Allo-HSC, n = 58 |
11 (85) |
1 (25) |
10 (53) |
6 (60) |
5 (50) |
25 (81)§ |
|
| No. with mismatch, n = 11 |
0 |
1 (25) |
5 (26) |
1 (10) |
4 (40) |
0 |
<0.05 |
| Survival, no. (%) | |||||||
| 2 mo | 5 (38) | 4 (100) | 13 (68) | 5 (50) | 10 (100) | 24 (77) | <0.0001 |
| 6 mo | 2 (15) | 4 (100) | 10 (53) | 5 (50) | 7 (70) | 18 (58) | <0.001 |
*HSC, hematopoietic stem cell. †This patient was receiving chemoprophylaxis. ‡1 patient was receiving chemoprophylaxis. §11 patients were receiving chemoprophylaxis.