Table 4. Characteristics of transplant patients with toxoplasmosis, according to graft type and comparison to overall graft population, Europe, 2010–2014*.
| Characteristics |
Allo-HSC |
|
Kidney |
|
Liver |
|
Heart |
p value |
||||
| Case-patients |
All TP |
Case-patients |
All TP |
Case-patients |
All TP |
Case-patients |
All TP |
|||||
| Patients, no. | 58 | 4,108 | 9 | 6,507 | 8 | 2,983 | 12 | 998 | NA | |||
| Age, y, mean ± SE | 46.8 ± 5.3 | 50.7 | 44.6 ± 5.9 | 50.9 | 55.1 ± 1.5 | 51.6 | 44.4 ± 6.4 | 47.5 | NA | |||
| Female sex, % |
43 |
38 |
|
44 |
63 |
|
38 |
30 |
|
17 |
22 |
NA |
| Male sex, % |
57 |
62 |
|
56 |
37 |
|
62 |
70 |
|
83 |
78 |
NA |
| Mean time diagnosis/graft, wk, mean ± SE | 20.6 ± 4.6 | NA | 198 ± 68 | ND | 152 ± 144 | ND | 441 ± 155 | ND | <0.0001 | |||
| Mean time diagnosis/death, d, mean ± SE |
47 ± 18 |
NA |
|
33 |
ND |
|
38 ± 17 |
ND |
|
NA |
ND |
0.8595 |
| Mismatched serologic results (D+/R–), no. (%) |
0 |
NA |
|
4 (33) |
NA |
|
3 (38) |
NA |
|
4 (33) |
NA |
0.8923 |
| 2-mo survival, no. (%) | 36 (62) | ND | 8 (89) | ND | 5 (63) | ND | 12 (100) | ND | <0.05 | |||
| Deep site involvement | 12 (43) | ND | 3 (60) | ND | 4 (57) | ND | 6 (100) | ND | 0.0513 | |||
| Fever only | 5 (100) | ND | 3 (100) | ND | 0 | ND | 2 (100) | ND | 1 | |||
| No clinical signs |
18 (72) |
|
|
1 (100) |
|
|
1 (100) |
|
|
4 (100) |
|
0.1407 |
| 6-mo survival, %† | 38 | 84‡ | 89 | 72 | 50 | 75§ | 100 | 60 | <0.0001 | |||
| Deep site involvement | 25 | NA | 60 | NA | 28 | NA | 100 | NA | <0.01 | |||
| Fever only | 40 | NA | 100 | NA | 0 | NA | 100 | NA | 0.2083 | |||
*D+, donor positive; NA, not applicable; ND, not determined; NS, not significant; R–, recipient negative; TP, transplant patients. †The survival rate for the general TP population was calculated at time similar to the mean time of diagnosis of toxoplasmosis after graft in case-patients. ‡p<0.01 compared with case-patients. §p<0.05 compared with case-patients.