Table. Drug resistance in leprosy patients with and without origins in American Samoa, USA, 2012–2015*.
| Sample no. | Clinical classification† | Drug susceptibility‡ |
DRDR sequence |
Location§ | |||
|---|---|---|---|---|---|---|---|
| Dapsone | Rifampin | folP1 | rpoB | ||||
| US patients of American Samoa origin | |||||||
| NHDP1 | BL | No | Yes | T53I | Wild type | Louisiana, USA | |
| NHDP2 | LL | Yes | Yes | Wild type | Wild type | Hawaii, USA | |
| NHDP3 | LL | No | Yes | P55R | Wild type | Washington, USA | |
| NHDP4 | LL | Yes | Yes | Wild type | Wild type | Massachusetts, USA | |
| NHDP5 (9) | BL | No | No | T53A | S456L | Hawaii, USA | |
| NHDP6 (8) |
LL |
No |
Yes |
|
P55L |
Wild type |
California, USA |
| US patients not of American Samoa origin | |||||||
| NHDP7 | BL | Yes | Yes | Wild type | Wild type | Africa | |
| NHDP8 | LL | Yes | Yes | Wild type | Wild type | Burma | |
| NHDP9 | LL | Yes | Yes | Wild type | Wild type | Micronesia | |
| NHDP10 | LL | Yes | Yes | Wild type | Wild type | Micronesia | |
| NHDP11 | LL-BL | Yes | Yes | Wild type | Wild type | Micronesia | |
| NHDP12 | BL | Yes | Yes | Wild type | Wild type | Micronesia | |
| NHDP13 | LL | Yes | Yes | Wild type | Wild type | Pacific Islands | |
| NHDP14 | LL | Yes | Yes | Wild type | Wild type | Pacific Islands | |
| NHDP15 | LL | Yes | Yes | Wild type | Wild type | Marshall Islands | |
| NHDP16 | BL | Yes | Yes | Wild type | Wild type | Marshall Islands | |
| NHDP17 | BL | Yes | Yes | Wild type | Wild type | Marshall Islands | |
| NHDP18 | BL | Yes | Yes | Wild type | Wild type | The Philippines | |
| NHDP19 | LL | Yes | Yes | Wild type | Wild type | The Philippines | |
| NHDP20 | BL | Yes | Yes | Wild type | Wild type | Alaska, USA | |
| NHDP21 | LL | Yes | Yes | Wild type | Wild type | Alaska, USA | |
| NHDP22 | LL | Yes | Yes | Wild type | Wild type | Florida, USA | |
| NHDP23 | LL | Yes | Yes | Wild type | Wild type | Florida, USA | |
| NHDP24 | LL | Yes | Yes | Wild type | Wild type | Florida, USA | |
| NHDP25 | LL-BL | Yes | Yes | Wild type | Wild type | Louisiana, USA | |
| NHDP26 | LL | Yes | Yes | Wild type | Wild type | Louisiana, USA | |
*BL, borderline leprosy; DRDR, drug resistance–determining region; LL, lepromatous leprosy; NHDP, National Hansen’s Disease Programs. †Classification according to the Ridley-Jopling scale. ‡Molecular drug susceptibility testing done according to the World Health Organization guidelines (6). A susceptible Mycobacterium leprae isolate had no mutations in the DRDR of folP1 or rpoB (i.e., the isolate was wild type). A drug-resistant M. leprae isolate had a mutation in the DRDR of the folP1 or rpoB gene (4,5). §Location for patients of American Samoa origin refers to the US state where the leprosy diagnosis was made. Location for patients not of American Samoa origin refers to their location of origin.