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Representative examples of two predominant mechanisms of activation in auto-immolative linkers: (A) elimination and (B) acyl transfer. Enzymatic catalysis releases a masking group (R1–CO2H). Then, elimination to form a quinone methide (A)27 or acyl transfer driven the action of a trimethyl lock (B)25 rapidly releases a fluorophore (R2–OH or R2–NH2).
