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. Author manuscript; available in PMC: 2018 Jul 23.
Published in final edited form as: Nat Chem Biol. 2017 Jul 24;13(9):982–993. doi: 10.1038/nchembio.2436

Figure 2. Two-dimensional hierarchical clustering of chemical-genetic interactions.

Figure 2

Mean negative chemical-genetic interactions are represented in red (n=3, technical replicates). Rows, 173 deletion mutant strains; columns, 1380 bioactive compounds from the high confidence set (HCS). Sections are expanded to allow detailed visualization of compounds targeting processes related to DNA replication & repair (i), mitosis and chromosome segregation (ii), glycosylation, protein folding/targeting, and cell wall biogenesis (iii), transcription and chromatin organization (iv), vesicle traffic (v), cell polarity and morphogenesis (vi).