Table 10.III.
Electrospun polymer matrices delivering antibiotics.
| Electrospun matrices | Drug | Activity | Ref. |
|---|---|---|---|
| PLGA/PEG-b-PLA diblock copolymer/PLA (80:15:5 wt%) | Cefoxitinsodium (Mefoxin®) | Prevent infections after surgery | (32) |
| PLGA | Tetracyclinehydrochloride | Protein synthesis inhibitors, active against gram + and gram - | (34) |
| PEUU/PLGA | Tetracyclinehydrochloride | Protein synthesis inhibitors, active against gram + and gram - | (35) |
| PLA/PCL | Tetracyclinehydrochloride | Protein synthesis inhibitors, active against gram + and gram - | (36) |
| PLA-collagene | Gentamicin | Post-operative infections due to S. epidermis, P. aeruginosa and E. coli | (37) |
| Halloysite clay nanotubes/PCL/gelatin | Metronidazole | Action on anaerobic and protozoal bacteria | (38) |
| Chitosan: PEO (90:10) | Ciprofloxacin hydrochloride (CipHCl) or moxifloxacin hydrochloride (Moxi) | Activity against E. coli and S. aureus | (39) |
| PVA/ SF | Ciprofloxacinhydrochloride | Activity against E. coli and S. aureus | (40) |
| PEG/PLA | Doxorubicinhydrocloride | Antineoplastic antibiotic | (41) |
| PDS | Vancomycin (VANC) and/or Rifampicin (RIF) | Activities on biofilms formed by S. aureus and S. epidermidis | (42) |
| PCL | Ampicillin sodium | Used to treat pharyngitis, tonsillitis and influenza caused by Haemophilus | (43) |
PEUU = poly(esterurethane) urea
SF = regenerated silk fibroin
PDS = polydioxanone