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. 2018 May 15;17(7):874–880. doi: 10.1080/15384101.2018.1456294

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© 2018 A*STAR. Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 1. — The GPI lipid anchor biosynthesis pathway – overview. The various steps of the pathway (from the N-acetylglucosaminyltransferase complex with PIG-A etc. to the step of leaving the ER where further anchor remodeling happens) are schematically depicted. All reactions and translocations are shown in white and black except for the six steps involving PIG-B, PIG-M, PIG-U, PIG-W, PIG-V, and PIG-Z that are highlighted in colors. Please note that PIG-U is a subunit of the transamidase complex and not all proteins, for example PIG-Z, are available in all organisms.