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. Author manuscript; available in PMC: 2018 Jul 23.
Published in final edited form as: Cell Rep. 2018 Jul 3;24(1):47–55. doi: 10.1016/j.celrep.2018.06.008

Figure 3. Controlled-Release Mitochondrial Protonophore Slows Tumor Growth in High-Fat-Fed ApcMin+/− Mice, a Murine Model of Familial Adenomatous Polyposis, by Reversing Hyperinsulinemia.

Figure 3

(A and B) Fasting plasma glucose (A) and insulin concentrations (B).

(C) Representative images of small intestine stained for β-catenin.

(D and E) Quantification of total polyp number (D) and area (E).

(F and G) Tumor glucose uptake (F) and oxidation (VPDH/VCS) (G).

In (A)–(E), n = 5 per group. In (F) and (G), n = 4–5 per group. In all panels, data are the mean ± SEM and groups were compared by ANOVA with Bonferroni’s multiple comparisons test. See also Figure S2.