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. Author manuscript; available in PMC: 2018 Jul 23.
Published in final edited form as: Cell Rep. 2018 Jul 3;24(1):47–55. doi: 10.1016/j.celrep.2018.06.008

Figure 4. Metformin Slows Tumor Growth in HFD Mice by Reducing Tumor Glucose Uptake and Oxidation Secondary to Hyperinsulinemia.

Figure 4

(A) Plasma, liver, and tumor metformin concentrations.

(B and C) Fasting plasma glucose (B) and insulin concentrations (C).

(D) Endogenous glucose turnover.

(E) Tumor size.

(F) In vitro proliferation of MC38 cells incubated in media containing metformin.

(G and H) Tumor glucose uptake (G) and oxidation (VPDH/VCS) (H).

In (A), n = 6. In (B)–(H), data are the mean ± SEM of n = 8 per group, with comparisons by ANOVA with Bonferroni’s multiple comparisons test. See also Figure S3.