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. Author manuscript; available in PMC: 2019 Jan 28.
Published in final edited form as: J Control Release. 2017 Nov 28;270:158–176. doi: 10.1016/j.jconrel.2017.11.045

Fig. 1:

Fig. 1:

Characterization of anti-CD38 chitosan NPs. A) Crosslinking reaction showing ionotropic gelation of chitosan with TPP anions (ChemDraw Professional 15.1 was used for the chemical drawings). B) Scheme representing anti-CD38 chitosan NPs loaded with bortezomib by conjugation of polymeric chitosan NPs with streptavidin and further coupling with biotinylated anti-CD38 monoclonal antibody. C) Effect of TPP crosslinker (0.25 – 1 mg/ml) on i) size and ii) stability of anti-CD38 chitosan NPs. D) TEM image of chitosan NPs showing 50μm size. E) In vitro BTZ release from anti-CD38 chitosan measured by HPLC after 72 h (n=3).