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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Bone. 2018 Jun 5;114:22–31. doi: 10.1016/j.bone.2018.06.002

Fig. 2. Mefloquine administration reverses the decrease in bone formation induced by aging.

Fig. 2

(A) MAR, MS/BS, and BFR/BS were measure in unstained sections of lumbar vertebra (n=7–10). (B) N.Ob/BS and Ob.S/BS were scored in lumbar vertebra stained with von Kossa/McNeal (n=7–10). (C) N.Oc/BS, Oc.S/BS, and ES/BS were scored in lumbar vertebra stained for TRAPase/Toluidine blue (n=7–8) in young and old mice. Bars represent mean ± s.d., #p<0.05 versus vehicle-treated young mice; *p<0.05 versus vehicle treated mice at the same age, by two-way ANOVA. Representative images from lumbar vertebra sections for the corresponding analysis are shown (red arrows; osteoblasts and black arrows; osteoclasts). All scale bars indicate 50μm.