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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Bone. 2018 Jun 5;114:22–31. doi: 10.1016/j.bone.2018.06.002

Fig. 4. Mefloquine-treated young, but not old mice exhibit changes in histomorphometric parameters in cortical bone.

Fig. 4

(A) MAR, MS/BS, and BFR/BS were measured in unstained sections of femoral mid-diaphysis (n=6–9). (B) N.Oc/BS, Oc.S/BS, and ES/BS were measured in cross-section of femoral mid-diaphysis stained for TRAPase (n=7–10). Representative images from osteoclasts on the bone surface (arrow, magenta) are shown. (C) Markers of bone resorption and formation were measured in serum from young and old mice treated with vehicle or mefloquine (n=6–10). Bars represent mean ± s.d., #p<0.05 versus vehicle-treated young mice; *p<0.05 versus vehicle treated mice at the same age, by two-way ANOVA. All scale bars indicate 50μm.