Table 1.
Biomechanical structural properties are altered in mefloquine-treated mice.
| Structural properties | ||||||
|---|---|---|---|---|---|---|
|
| ||||||
| young + vehicle | young + mefloquine | old + vehicle | old + mefloquine | p value (two-way ANOVA) | ||
|
| ||||||
| Yield force (N) | 11.59 ± 2.11 | 10.71 ± 1.68 | 9.47 ± 4.25 | 11.19 ± 2.02 | age | 0.411 |
| treatment | 0.667 | |||||
| age × treatment | 0.197 | |||||
|
| ||||||
| Ultimate force (N) | 16.57 ± 3.09 | 15.03 ± 1.57 | 19.85 ± 4.59 | 17.61 ± 4.61 | age | 0.031 |
| treatment | 0.153 | |||||
| age × treatment | 0.787 | |||||
|
| ||||||
| Displacement to yield (μm) | 142.49 ± 36.86 | 142.12 ± 23.45 | 94.70 ± 22.23 | 122.23 ± 46.56 | age | 0.007 |
| treatment | 0.250 | |||||
| age × treatment | 0.238 | |||||
|
| ||||||
| Postyield displacement (μm) | 484.88 ± 303.07 | 706.76 ± 394.22 | 380.83 ± 217.01 | 418.99 ± 195.36 | age | 0.071 |
| treatment | 0.223 | |||||
| age × treatment | 0.386 | |||||
|
| ||||||
| Total displacement (μm) | 627.37 ± 307.50 | 848.88 ± 393.39 | 475.53 ± 208.39 | 593.33 ± 190.75 | age | 0.059 |
| treatment | 0.113 | |||||
| age × treatment | 0.621 | |||||
|
| ||||||
| Stiffness (N/mm) | 105.23 ± 25.58 | 89.80 ± 19.57 | 115.01 ± 37.86 | 121.63 ± 37.50 | age | 0.070 |
| treatment | 0.693 | |||||
| age × treatment | 0.327 | |||||
|
| ||||||
| Work to yield (mJ) | 0.85 ± 0.28 | 0.83 ± 0.19 | 0.56 ± 0.27 | 0.79 ± 0.41 | age | 0.131 |
| treatment | 0.312 | |||||
| age × treatment | 0.224 | |||||
|
| ||||||
| Postyield work (mJ) | 5.94 ± 2.19 | 8.17 ± 3.40 | 5.59 ± 2.74 | 6.31 ± 3.13 | age | 0.298 |
| treatment | 0.167 | |||||
| age × treatment | 0.474 | |||||
|
| ||||||
| Total work (mJ) | 6.78 ± 2.22 | 9.00 ± 3.36 | 6.14 ± 2.66 | 6.61 ± 3.11 | age | 0.147 |
| treatment | 0.198 | |||||
| age × treatment | 0.396 | |||||
Bolded values p<0.05 vs. vehicle-treated young mice, by post hoc analysis (n=7–9/treatment group).