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. Author manuscript; available in PMC: 2019 Jul 23.
Published in final edited form as: Cancer Immunol Res. 2018 Jan 23;6(3):305–319. doi: 10.1158/2326-6066.CIR-16-0358

Figure 1. Generation of spontaneous HPV buccal tumors in immunocompromised mice.

Figure 1

(A) Schematic of plasmids used to induce oral tumors by oncogene transfection. (B) Immunocompromised, athymic nude mice (NCr strain, n=5/group) received plasmids once through submucosal injection followed by electroporation in the buccal area. Different combinations of plasmids are indicated in the legend. The bioluminescence image was recorded by IVIS Spectrum after IP injection of luciferin solution. (C) Percent tumor-free survival. Three independent experiments were performed. P values were calculated by log-rank test (C). P values < 0.05 were considered significant. Data are presented as mean ± SD.