Table 2.
Temporal Trends in Risk of Death Among Persons with ESRD due to Granulomatosis with Polyangiitis (1995–2014)
| Year of ESRD Initiation | N | # Deaths* | Incidence of Death/100-patient years (95% CI) | Age- and Sex -Adjusted Hazard Ratio (95% CI) | Multivariate† Adjusted Hazard Ratio (95% CI) |
|---|---|---|---|---|---|
| 1995–1999 | 1,104 | 365 | 19.0 (17.2–21.1) | 1.0 (reference) | 1.0 (reference) |
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| 2000–2004 | 1,345 | 403 | 16.9 (15.4–18.7) | 0.89 (0.76–1.04) | 0.90 (0.77–1.05) |
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| 2005–2009 | 1,728 | 521 | 16.2 (14.9–17.7) | 0.80 (0.69–0.93) | 0.82 (0.71–0.96) |
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| 2010–2014 | 1,752 | 506 | 15.3 (14.0–16.7) | 0.75 (0.65–0.87) | 0.77 (0.66–0.90) |
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| P-for-trend | 0.01 | <0.001 | 0.005 | ||
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*
Number of deaths and total follow up determined using the end of the subcohort (e.g., December 31st 1999 for the 1995–1999 subcohort) as the censoring date;
†
Adjusted for age, sex, BMI, diabetes, hypertension, current smoker, CAD, CHF, CVA, region, and first modality