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. 2018 Jul 23;8:11097. doi: 10.1038/s41598-018-29378-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gene set enrichment analysis performed with GSEA on 20501 genes list sorted according to the correlation between their expression level and VWA2 expression in 594 CRC cancers from the TCGA. The two gen sets with strongest association were HALLMARK_WNT_BETA_CATENIN_SIGNALING (MutSigDB M5895, genes up-regulated by activation of WNT signaling through accumulation of beta catenin CTNNB1, left) and HALLMARK_MYC_TARGETS_V2 (MutSigDB M5928, A subgroup of genes regulated by MYC - version 2, right). A complete list of results is available in Supplementary Table ST6.