Table 1.
Clinico-pathological characteristics of 81 CRC cases classified according to VWA2 methylation analyzed by MS-AFLP.
| No Somatic Hypomethylation | Somatic Hypomethylation | P-value | ||
|---|---|---|---|---|
| Total | 67 (83%) | 14 (17%) | ||
| Gender | Female | 30 (79%) | 8 (21%) | 0.56 |
| Male | 37 (86%) | 6 (14%) | ||
| Race | Caucasian | 40 (83%) | 8 (17%) | 0.76 |
| African Amer. | 21 (81%) | 5 (19%) | ||
| Age | 63.6 ± 10.7 | 74.3 ± 12.1 | 0.007 | |
| Tumor | Proximal | 38 (84%) | 7 (16%) | 0.57 |
| Location | Distal | 27 (79%) | 7 (21%) | |
| MSI status | MSS | 58 (83%) | 12 (17%) | 1.0 |
| MSI | 8 (80%) | 2 (2%) | ||
| TP53 | Wild Type | 31 (84%) | 6 (16%) | 1.0 |
| Mutant | 29 (85%) | 5 (15%) | ||
| KRAS | Wild Type | 40 (87%) | 6 (13%) | 0.52 |
| Mutant | 22 (81%) | 5 (19%) | ||
| BRAF | Wild Type | 50 (85%) | 9 (15%) | 0.61 |
| Mutant | 6 (75%) | 2 (25%) | ||
In parentheses, the percentage of cases without or with somatic hypomethylation within each studied group (in rows). P-values were calculated by Fisher’s exact test except for patient age, where Student’s t-test was applied. In bold, P-values < 0.01.