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. 2018 Jul 23;8:11107. doi: 10.1038/s41598-018-29502-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic diagram showing proposed pathway through which cyclic mechanical loading regulates primary cilia expression to control tendon matrix turnover. Mechanical loading disrupts primary cilia expression via TGFβR and HDAC6 activation. This in turn may modulate cilia signalling, including suppression of TGFβ signalling as part of a negative feedback mechanism regulating tendon matrix turnover in response to mechanical loading.