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. 2018 Jul 23;8:11056. doi: 10.1038/s41598-018-29212-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Plot of the first two principal components of the abundance of the 13 compounds showing the increase of the abundance at day 28. The plot accounts for more than 78% of the total variance of the data. No separation among the groups is observed except the hiPSCs at day 28. The largest departure from the average of the distribution is found in those mice, labelled as DA and DS, that eventually developed the largest teratomas.