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. 2018 Jul 23;8:11044. doi: 10.1038/s41598-018-29411-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of Cys C in Lacrimal glands and Lysates of Male NOD mice compared to BALB/c mice. Cys C concentration in (A) tears (n = 7 NOD and 7 BALB/c) and (B) LG lysates (n = 6 BALB/c and 6 NOD) from 12 week males as determined by Western blotting and quantification of Cys C signal by pixel intensity per µg protein. Representative blot is shown, Full length blot is shown in (Supplementary Fig. 1). Values are presented as a percentage of those detected in BALB/c mouse samples, set at 100%. Error bars show SE; ***p < 0.001, ****p < 0.0001. (C) Immunofluorescence labeling of sections from LG of 12 week male BALB/c and NOD mouse LG for Cys C. Green, Cys C (labeled with Alexa-488 conjugated secondary antibody) and red, actin filaments labeled with rhodamine-phalloidin. (D) Relative gene expression of Cys C in LG acinar cells from 12 week male BALB/c (n = 6) and NOD (n = 6) mice isolated by laser capture microdissection.