Table 3.

Comparison of receiver operating characteristics (ROC) between the four biomarkers, Cathepsin S (CTSS), secretory IgA (sIgA), Lactoferrin (LF) and Cystatin C (Cys C) as predictors of Sjögren’s Syndrome (SS)^*.

	SS vs Total Autoimmune**		SS vs Dry Eye
	ROC (95% CI)	P ***	ROC (95% CI)	P ***
CTSS	0.919 (0.851–0.986)		0.840 (0.740–0.940)
sIgA	0.835 (0.740–0.982)		0.899 (0.819–0.978)
LF	0.864 (0.787–0.939)		0.908 (0.841–0.975)
Cys C	0.897 (0.602–0.855)		0.729 (0.602–0.855)
CTSS + sIga	0.922 (0.856–0.989)	0.62	0.905 (0.828–0.983)	0.16
CTSS + LF	0.931 (0.870–0.993)	0.24	0.939 (0.878–1.000)	0.02 (0.18****)
CTSS + Cys C	0.961 (0.870–0.988)	0.11	0.857 (0.758–0.956)	0.63

^*Primary and secondary Sjögren’s Syndrome combined.

^**Rheumatoid Arthritis patients and patients with autoimmune diagnosis other than Rheumatoid Arthritis combined.

^***p-value against CTSS alone.

^****p-value against LF alone.