Table 2.

Gene expression of the TCA cycle genes was entirely downregulated in tumor tissues of both Patient-1 and -2 via whole-transcriptome analysis

Gene name		Fold-change (tumor/normal)
		Patient-1	Patient-2
CS	Citrate synthase	0.28	0.45
ACO1	Aconitase 1, soluble	NA	0.77
ACO2	Aconitase 2, mitochondrial	0.031	0.17
IDH1	Isocitrate dehydrogenase 1 (NADP+), soluble	3.27	2.11
IDH2	Isocitrate dehydrogenase 2 (NADP+), mitochondrial	0.21	0.52
IDH3A	Isocitrate dehydrogenase 3 (NAD+) alpha	0.13	0.28
IDH3B	Isocitrate dehydrogenase 3 (NAD+) beta	0.26	0.49
IDH3G	Isocitrate dehydrogenase 3 (NAD+) gamma	1.09	0.65
OGDH	Oxoglutarate (alpha-ketoglutarate) dehydrogenase	0.18	0.19
OGDHL	Oxoglutarate dehydrogenase-like	0.12	0.12
DLD	Dihydrolipoamide dehydrogenase	0.11	0.45
DLST	Dihydrolipoamide S-succinyltransferase	0.43	0.68
SUCLG1	Succinate-CoA ligase, alpha subunit	0.30	0.38
SUCLG2	Succinate-CoA ligase, GDP-forming, beta subunit	0.22	0.57
SUCLA2	Succinate-CoA ligase, ADP-forming, beta subunit	0.12	0.39
SDHA	Succinate dehydrogenase complex, subunit A,	0.10	0.46
SDHB	Succinate dehydrogenase complex, subunit B,	0.19	0.33
SDHC	Succinate dehydrogenase complex, subunit C,	0.39	0.63
SDHD	Succinate dehydrogenase complex, subunit D,	NA	0.63
FH	Fumarate hydratase	0.20	0.22
MDH1	Malate dehydrogenase 1, NAD (soluble)	0.091	0.20
MDH2	Malate dehydrogenase 2, NAD (mitochondrial)	0.17	2.35
GOT1	Glutamic-oxaloacetic transaminase 1, soluble	0.047	0.13
GOT2	Glutamic-oxaloacetic transaminase 2, mitochondrial	0.16	0.22