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. 2018 Jul 23;8:11022. doi: 10.1038/s41598-018-29398-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Facilitated mechanical sensitivity of C-fibre nociceptors in mice lacking IL-27/WSX-1 signalling. (a) Sample recordings of peri-stimulus time histogram. Abscissa: time in seconds. Ordinate: discharge rate of C-nociceptors. Lowest trace: force output of the mechanical stimulus. (b) Summarised mechanical response patterns. The response magnitude was significantly greater in WSX-1^−/−, EBI3^−/−, and p28^−/− mice compared with WT. (a,b) WT (n = 28), WSX-1^−/− (n = 29), EBI3^−/− (n = 25), p28^−/− (n = 19). P < 0.01–0.001. Kruskal-Wallis test followed by Dunn’s multiple comparison test. (c) Reduced mechanical response magnitude in EBI3^−/− mice treated with rIL-27 compared with non-treated EBI3^−/− mice. P < 0.001. Mann-Whitney U test. The data for non-treated EBI3^−/− mice in panel c are identical to those of the EBI3^−/− mice in panel b.