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. 2018 Jul 23;8:11073. doi: 10.1038/s41598-018-28885-x

Figure 3.

Figure 3

Contributions of hippocampal neurotransmitters to contextual fear memory in LAO1 KO mice. (a) The concentrations of acetylcholine, serotonin, and dopamine in the hippocampus of male WT mice treated with saline, LAO1 KO mice treated with saline, and LAO1 KO mice treated with donepezil were measured using LC-MS/MS. (b,c) Passive avoidance test. Adult male WT mice treated with saline (n = 22), WT mice treated with donepezil (n = 20), LAO1 KO mice treated with saline (n = 22), and LAO1 KO mice treated with donepezil (n = 20) received a foot shock in the dark compartment on the first day. The results represent the percentage of time spent avoiding the dark compartment by the mice at 3 h, 1 and 3 days after the foot shock.