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. 2018 Jul 23;8:11073. doi: 10.1038/s41598-018-28885-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Changes in amino acid metabolites in the hippocampus of LAO1 KO mice. (a) Heat map of the relative significant changes in the hippocampus of male WT and LAO1 KO mice (n = 5 per group). The heat map ranges from −2 to +2 on a log2 scale. (b) Histograms of typical metabolite changes between male WT and LAO1 KO mice (n = 5 per group). (c) Schematic diagram showing Phe metabolism. LAO is the metabolic enzyme that converts Phe to phenylpyruvic acid and Tyr to acetoacetic acid via 4-hydroxy-phenylpyruvic acid.