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Schematic diagram showing metabolomic changes observed in LAO1 KO mice. In the hippocampus of LAO1 KO mice, Phe and Tyr accumulation occurs owing to dysfunction in Phe metabolism. High levels of Tyr lead to elevated dopamine and the accumulation of Phe inhibits PK mRNA expression. Reduced levels of PK affect glycolysis and decrease acetyl coenzyme A synthesis. Finally, low levels of acetylcholine are observed in the hippocampus of LAO1 KO mice.
