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. 2018 Jul 23;8:11043. doi: 10.1038/s41598-018-29401-x

Figure 3.

Figure 3

Humoral immune responses against ZIKV after vaccination and challenge. IFNAR−/− mice were IM vaccinated with a single dose of vaccine 28 days prior to lethal ZIKV challenge. ELISA results depicting the levels of ZIKV antigen-specific IgG present in serum samples collected on day 0, 7 and 42 after lethal ZIKV challenge. (A) ZIKV E; (B) ZIKV prM; (C) ZIKV NS1. (D) ZIKV neutralizing activity of mouse serum samples as measured by the half maximal effective concentration (EC50). Statistically significant differences are indicated as follows: ****p < 0.0001, ***p < 0.001, **p < 0.01 and *p < 0.05.