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. 2018 Jul 23;8:11058. doi: 10.1038/s41598-018-29302-z

Figure 4.

Figure 4

Myotubes action potential characteristics. (A) The rheobase current was significantly reduced in patient 1 compared to patient 2. Indeed, representative tracks show that, in the first case, a 350 pA stimulus was sufficient to evoke an AP, while the patient 2 a 550 pA current was needed in. (B) Uprising phase slope/overshoot relationship. The maximum voltage value reached by evoked APs was higher and the (dV/dt)MAX was faster in patient 1 (n = 34) compared to patient 2 (n = 30) in correspondence of every current stimulus applied. Here for seek of clarity, only three stimuli were shown. In the figure *p < 0.05.