Table 2.
Short- and long-range FCD alterations in ALS patients compared with healthy controlsa.
| FCD | Cluster index | Brain regions | Brodmann’s area | Brainnetome atlas subregionb | Cluster size (voxels)c | Peak MNI coordinate (x, y, z) | Peak intensity (t- value) |
|---|---|---|---|---|---|---|---|
| Short-range FCD | HC > ALS | ||||||
| 1 | Right lingual gyrus | 19 | rLinG (Brainnetome #196) | 37 | 18, -51, -12 | 3.2628 | |
| 2 | Left superior temporal gyrus | 41 | TE1.0 and TE1.2 (Brainnetome #73), A41/42 (Brainnetome #71) | 62 | -54, -21, 6 | 4.011 | |
| 3 | Right precentral gyrus | 4 | A4t (Brainnetome #60) | 60 | 24, -24, 51 | 3.3177 | |
| HC < ALS | |||||||
| 4 | Left inferior parietal lobule, left angular gyrus | 40, 39 | A40c (Brainnetome #141), A39rd (Brainnetome #137) | 48 | -45, -54, 42 | -3.4677 | |
| Long-range FCD | HC > ALS | ||||||
| 5 | Vermis VI | / | Cerebellum_Vermis_VI (Brainnetome #252) | 65 | 0,-69,-6 | 4.4033 | |
| 6 | Left superior temporal gyrus, left heschl gyrus, left middle temporal gyrus, left rolandic operculum | 41, 22 | TE1.0 and TE1.2 (Brainnetome #73), A41/42 (Brainnetome #71), aSTS (Brainnetome #87), A22c (Brainnetome #75) | 172 | -45, -27, 0 | 4.154 | |
| 7 | Right superior temporal gyrus, right middle temporal gyrus | 21, 22, 42 | rpSTS (Brainnetome #122), TS (Brainnetome #124) | 41 | 54, -42, 12 | 3.5023 | |
| 8 | Right rolandic operculum, right insula, right heschl gyrus | 13 | A40rv (Brainnetome #146), G (Brainnetome #164) | 87 | 36, -24, 18 | 3.9736 | |
| 9 | Left middle cingulate gyrus | 23 | A23c (Brainnetome #185), A23d (Brainnetome #175) | 63 | -6, -24, 27 | 3.7521 | |
| HC < ALS | |||||||
| 10 | Right precentral gyrus, right superior frontal gyrus, right middle frontal gyrus | 6 | A6cdl (Brainnetome #56), A4ul (Brainnetome #58) | 67 | 39, -9, 63 | -4.0984 | |
aThis result was computed in no global signal regression condition. Supplementary Table S1 was obtained in global signal regression condition. bBrainnetome Atlas, a brain atlas based on connectional architecture, http://atlas.brainnetome.org. cStatistical significance was set at a voxel-wise p < 0.01, in conjunction with cluster wise AlphaSim (rmm = 5, clusters = 36) to correct for multiple comparisons.