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. 2018 Jul 17;10:19. doi: 10.3389/fnsyn.2018.00019

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Copyright © 2018 McGowan, Mirabella, Hamod, Karakhanyan, Mlynaryk, Moore, Tischfield, Hart and Pang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hsa-let-7c overexpression alters synaptic transmission in human iN cells. (A–D) let-7c overexpression significantly reduced the density but not size or fluorescence intensity of synapsin⁺ puncta in AG2U iPS-derived induced neurons. (E) Representative traces of spontaneous excitatory post-synaptic currents (sEPSCs) in control and let-7c infected iN cells. (F) Overexpression of let-7c does not decrease the incidence of sEPSCs in either cell line. (G) let-7c overexpression results in a significant decrease in sEPSC frequency in AG2U iPS-derived induced neurons. (H) The amplitude of sEPScs is significantly decreased by let-7c overexpression in the AG2U cell line. Statistical tests were performed using two-tailed Student’s t-test, where *p < 0.05, **p < 0.01.