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. 2018 Jul 17;9:913. doi: 10.3389/fphys.2018.00913

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Copyright © 2018 Lourenço, Ledo, Caetano, Barbosa and Laranjinha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Glutamate-induced changes in •NO, Cerebral Blood Flow and O₂ in the dentate gyrus of the hippocampus of anesthetized F344 rats. (A) Representative recording of amperometric signals of •NO (blue line), cerebral blood flow (red line) and amperometric signals of O₂ (green line) during glutamatergic activation. Glutamate (0.5 nmol, 1 s) was locally applied by pressure ejection at the time indicated by the upward arrows. (B) Detailed temporal correlation between the dynamic changes in the •NO concentration, CBF and O₂ tension.