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. 2018 Jul 17;9:913. doi: 10.3389/fphys.2018.00913

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Copyright © 2018 Lourenço, Ledo, Caetano, Barbosa and Laranjinha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quantitative analysis of biphasic changes in oxygen tension coupled to the glutamatergic activation in the dentate gyrus of hippocampus of F344 rats along aging and relationship with cerebral blood flow changes. (A) Average decrease in ΔpO₂ in the initial component of the signal and (B) average increase in ΔpO₂ in the later phase coupled to the CBF increase. Each bar represents mean ± SEM. ^∗p < 0.05. (C) Ratio of the pO₂ change to the CBF change in young and old-aged animals. (D) Cross-correlation analysis of the time course of CBF and O₂ dynamics elicited by glutamate in young and old-aged animals. Average strongest correlation (grey circles) was found at 2 s and 9 s delay of O₂ relative to CBF in young and old rats, respectively. All the values represent the mean ± SEM. ^∗p < 0.05.