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. 2018 Jul 17;11:248. doi: 10.3389/fnmol.2018.00248

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Copyright © 2018 Sun, Zhou, Ba, Feng, Hu, Cheng, Liu, Guo, Xiao, Jiang, Xiong, Hao, Chen and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Electrophysiological recording in Lamina II neurons of rat spinal cord upon different pharmacological treatments. (A) Effect of OT (1 μM) on GABAergic spontaneous transmission in the presence of strychnine (1 μM), a glycine-receptor antagonist. (B) Effect of OT (1 μM) on mininature GABAergic transmission in the presence of strychnine (1 μM) and TTX (0.5 μM). (C,D) Analyzed data of the frequency (C) and amplitude (D) of spontaneous and mininature IPSC before and after OT application in Lamina II neurons. Mean ± SEM, n = 8. One-way ANOVA followed by two-tailed t-test with Bonferroni correction. (E) Effect of OT (1 μM) on capsaicin-induced glutamatergic spontaneous excitatory transmission in Lamina II neurons. (F) Effect of OT (1 μM) on capsaicin-induced mininature glutamatergic excitatory transmission in Lamina II neurons. (G,H) Analyzed data of the frequency (G) and amplitude (H) of capsaicin-induced spontaneous and mininature EPSC before and after OT application in Lamina II neurons. Mean ± SEM, n = 6. One-way ANOVA followed by two-tailed t-test with Bonferroni correction. (I) Effect of saclofen (50 μM) on the inhibitory effects of OT on capsaicin-induced glutamatergic spontaneous excitatory transmission in Lamina II neurons. (J,K) Analyzed data of the frequency (G) and amplitude (H) of capsaicin-induced spontaneous EPSC after saclofen co-application with or without OT in Lamina II neurons. Mean ± SEM, n = 6. One-way ANOVA followed by two-tailed t-test with Bonferroni correction.