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. 2018 Jul 17;6:97. doi: 10.3389/fbioe.2018.00097

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Copyright © 2018 Cattin, Ramont and Rüegg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Co-culture with endothelial cells under 3D conditions inhibits SW620 and HCT116 spheroid growth in vitro. (A) Representative images of Ea.hy296 cells expressing Azurite cultured for 8 days under 3D conditions. (B) Representative images of HCT116-LifeAct-GFP cells cultured under 3D conditions with Ea.hy296-Azurite-cells and fibroblasts-LifeAct-mCherry cells. (C) Representatives brightfield images of SW620 and HCT116 colon cancer cells cultured for 7 days under 3D conditions in presence or absence of fibroblasts ± Ea.hy296 endothelial cells. (D) Quantification of relative size of SW620 and HT116 spheroids after 7 days of 3D culture. Quantification data represent mean values ± SD. White bars represent 500 μm. **p ≤ 0.01, ***p ≤ 0.001, and ****p ≤ 0.0001.