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. 2018 Jul 17;9:581. doi: 10.3389/fneur.2018.00581

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Copyright © 2018 Li, Weiland, Chen, Lan, Han, Durham, Liu, Wan, Ziai, Hanley and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microglia and monocyte-derived macrophages at 3 days after intracerebral hemorrhage. (A) Bleeding in the brain tissue is evident by the presence of red blood cells (r). (B,C) Reactive phagocytic microglia (mi) are shown engulfing red blood cells (r) and necrotic neurons (N). (D) A blood vessel (V) is shown with white blood cells, including monocytes (M). Red arrowhead indicates a blood vessel endothelial cell (i). Macrophages (Ma) can be seen phagocytosing red blood cells (r) (ii) and other debris (iii). Scale bars: (A–C,Dii,iii) 2 μm; (D) 10 μm. n = 6 animals per group.