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. 2018 Jul 17;9:1580. doi: 10.3389/fmicb.2018.01580

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Copyright © 2018 Latorre, Quenti, Travisany, Singh, Murray, Maass and Cambiazo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptional response in the absence of Fur. (A) Global transcriptional analysis of E. faecalis wild type and Δfur growing in the iron control condition. RNAseq differentially expressed genes classify by COG super-class categories. Color bars represent the upregulated or downregulated genes in Δfur compared to the wild type. Asterisk denotes significant enrichment in the bacterial genome (p (0.05) compared to total proportion. (B) Fur regulon of E. faecalis. Consensus logo of Fur regulon created with Fur DNA sequence found in promoters of EF0188, EF0191–EF0193, EF475–EF0476, and EF3082–EF3085 operons (the black arrow indicates palindromic sequence). (C) The graph contains 23 nodes (14 operons, 8 transcription factor families) connected by 26 edges (putative binding sites). Color circles represents COG super-class categories.