Table 1.
The differences between mice O-NALT and D-NALT.
| O-NALT | D-NALT | References | |
|---|---|---|---|
| Number of lymphocytes | + | ++ | Rodríguez-Monroy et al. (2007) |
| T/B cells ratio | 0.76–1.2 | 0.33–1.0 | Asanuma et al. (1997), Rodríguez-Monroy et al. (2007) |
| Percentage of B cellsa | 47–79% | 55–74% | Liang et al. (2001), Rodríguez-Monroy et al. (2007) |
| Plasma cells | + | ++ | Rodríguez-Monroy et al., (2007) |
| IgM+ B cells | 47 or 85% | 0.5–9% | Rodríguez-Monroy et al. (2007), Shikina et al. (2004), Smith et al. (2013) |
| IgA+ B cells | 1–1.6% | 7.7–10.8% | |
| B220+hi B cells | Present | Present | Rodríguez-Monroy et al. (2007) |
| B220+hi B220+low B cells | Absent | Present | |
| IgM/IgG/IgA secreting cells ratio (Uninfected) | 10/3/3 | 10/3/3 | Asanuma et al. (1997) |
| IgM/IgG/IgA secreting cells ratio (infected with influenza)b | 4/50/40 | 1/25/10 | |
| IgM/IgG/IgA secreting cells ratio(immunized with Cry1Ac protoxin)c | 1/80/125 | 1/125/350 | Rodriguez-Monroy and Moreno-Fierros (2010) |
| IgM/IgG/IgA secreting cells ratio(immunized with cholera toxin) | 1/30/65 | 1/90/160 | |
| IgA isotype class switching | Present | Absent | Shikina et al. (2004) |
| Class switch recombination-associated molecules | Present | Absent | |
| Long-lasting, specific effector antibody responsee | Absent | Present | Liang et al. (2001) |
| Frequency of AFCse | + | ++ | Liang et al. (2001) |
| Generation of virus-specific antibody forming cells (AFCs)e | + | + | |
| Infected/uninfected IFN-γ production ratiod | ~1000 | ~700 | Asanuma et al. (1997) |
| Infected/uninfected IL4 production ratio | 1 | 2 | |
| CD3+ T cells | 30–40% | 13–20% | Rodríguez-Monroy et al. (2007), Smith et al.(2013) |
| CD4+/CD8+ T cells ratio | 3–4.4 | 1.5–6.4 | Asanuma et al. (1997), Heritage et al. (1997), Rodríguez-Monroy et al. (2007), Smith et al.(2013) |
| αβ /γδ of CD3+ T cells ratio | 49–100 | 2.5–3 | Heritage et al. (1997) |
| αβ /γδ of CD4+ CD8- T cells ratio | 49–100 | 49–100 | |
| αβ /γδ ofCD4- CD8+ T cells ratio | 49–100 | 9–19 | |
| αβ /γδ ofCD4- CD8- T cells ratio | 0–1 | 0–1 | |
| Type of CD4+ T cells | Th0 | Th2 | Hiroi et al.(1998), Liang et al. (2001) |
Summary of major immune characteristics of mammalian organized and diffuse NALT in mice: ++ = high, + = low.
a
C57BL/6 mice have higher B cells percentage compared to BALB/c mice.
b
7 days post infection (dpi) with influenza.
c
BALB/c mice immunized intranasally.
d
7 dpi with influenza.
e
shows responses after influenza virus infection.