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. 2018 Jul 17;9:393. doi: 10.3389/fendo.2018.00393

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Copyright © 2018 Cusan, Mungo, De Marco Zompit, Segatto, Belletti and Baldassarre.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distribution of germline and somatic CDKN1B mutations. (A) Pie graphs report the distribution of germline mutations in hereditary syndromes (left) and somatic ones in sporadic cancers (right). The percentage of each type of pathogenic variant (frameshift, including both insertion and deletions, missense, and nonsense) is reported. (B) Distribution of mutations identified in breast cancer (top), prostate cancer (middle), and SI-NET (bottom) are depicted along the sequence of p27 protein.