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Huan et al. (30) uncovered a blood pressure associated SNP (rs3184504) in SH2B3, which also associates with the expression (eQTL) of several genes, including SH2B3 itself, in the genetically inferred causal blood pressure gene sets. Rs3184504 has been previously also associated with CAD risk. (9) Black arrows indicate association findings. Red arrows indicate the presumed functional cascade leading to CAD.
