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Recently, Holdt et al. (69) demonstrated that circANRIL regulates the maturation of precursor ribosomal RNA (pre-rRNA), by this impairing ribosome biogenesis and inducing nucleolar stress and apoptosis in vascular smooth muscle cells and macrophages. Moreover, carriers of the CAD-protective haplotype at 9p21 showed significantly increased expression of circANRIL.
