Table 1.
Genetic variation related to CAD/MI risk that has been associated with other down-stream omics layers such as transcriptome (mRNA, microRNAs and lncRNAs), epigenome, proteome or metabolome.
| Data type | Tissue | Phenotypic Trait | SNP | Omics-Marker | Refernces |
|---|---|---|---|---|---|
| Transcriptome: mRNAs | Visceral abdominal fat | HDL cholesterol level | rs4148008 | ABCAB/ABCA5 | Franzén et al. (28) |
| rs11869286 | STARD3 | ||||
| Total cholesterol level | rs751557 | EVI5 | |||
| rs174546 | TMEM258 | ||||
| LDL cholesterol level | rs12046679 | PCSK9 | |||
| CAD | rs892006 | G3BP1 | Foroughi Asl et al. (29) | ||
| rs6908994 | PSORSIC3 | ||||
| rs9930148 | FLYWCH1 | ||||
| Internal mammary artery, atherosclerotic aortic root | rs7500448 | CDH13 | Nelson et al. (13) | ||
| Blood | Blood pressure | Rs3184504 | SH2B3,ALDH2,NAA25(cis) and IL8,TAGAP (trans) | Huan et al. (30) | |
| Transcriptome: microRNAs | Circulating leukocytes, human coronary artery smooth muscle cells (HCASMC) | CAD | rs12190287 | miR-224: TCF21 | Miller et al. (31) Bastami et al. (32) |
| The effect of diet on plasma lipid levels | rs13702 | miR-410:LPL | Richardson et al. (33) | ||
| CAD | rs989727(rs7808424) | miR-202-5p:ASZ1 | Bastami et al. (34) | ||
| rs41269915(rs2229238) | miR-485-5p:UBE2Q1 | ||||
| rs15563 | hsa-miR-130a-5p:UBE2Z | Brænne et al. (16) | |||
| rs3088442 | hsa-miR-130a-5p:SLC22A3 | ||||
| rs2266788 | hsa-miR-4722-5p:APOA5 | ||||
| rs72932707 | hsa-miR-4722-5p:ICA1L | ||||
| HDL,LDL, and total cholesterol,triglycerides | rs2370747(rs7115089 | miR-100-5p,miR-125b-5p | Huan et al. (35) | ||
| CAD | rs11042699 (rs6578985) | miR-483-3p-IGF2 | |||
| Platelet count | rs4905998 rs(7149242) | miR-127-3P, miR-134, miR-370, miR-376a-3p, miR-382-5p, miR-431-5p, miR-433, miR-329, miR-409-3p, miR-494, miR-411-3p, miR-654-5p, miR-668, miR-543, miR-323a-3p, miR-337-3p | |||
| 3p/5p ratio | rs13064131 | miR-28:LPP | Civelek et al. (36) | ||
| Transcriptome:lnc RNAs | Internal mammary artery, atherosclerotic aortic root | CAD | rs1333045 | FPKM1_group_33469_transcript_1 | Ballantyne et al. (37) |
| MI | rs1333049 | FPKM1_group_33469_transcript_2 | |||
| T2D | rs2383208 | FPKM1_group_33469_transcript_6 | |||
| Early MI | rs10757274 | ANRIL | McPherson et al. (38) | ||
| Epigenome:DNA methylation | Hypertension | rs113460564, rs12443878, rs12444338, rs62040565, rs8060301 | CDH13 | Putku et al. (39) | |
| Diastolic blood pressure,serum high-density lipoprotein,high molecular weight adiponectin | rs8060301 | Cg09415485(CDH13) | |||
| High molecular weight adiponectin | rs2239857, rs77068073 | CDH13 | |||
| Smoking(no assosciation) | rs75509302 | cg23576855(AHRR) | |||
| LDL cholesterol level | rs563290 (rs515135, rs562338) | Cg05337441(APOB) | Hedman et al. (27) | ||
| Proteome | Blood plasma | CAD | rs12740374 | Granulin(CELSR2/SORT1) | Chen et al. (40) |
| rs867186 | Protein C (PROCR) | Howson et al. (14) | |||
| rs1050362 | apolipoprotein L1 (DHX38) | ||||
| Metabolome | Blood plasma | CAD | rs715 | CPS1,urea cycle metabolites,plasma glycine | Hartiala et al. (41) |
| Blood plasma | rs10450989(USP3), rs2228513(HER-C1)rs930491,rs11827377(STIM1), rs3853422(SEL1L),rs1869075(F-BXO25),rs9591507,rs17573278,rs894840,rs9285184(SUGT1) | Circulating short-chain di-carboxylacylcarnitine(SC-DA) | Kraus et al. (42) | ||
| Multi-OMICS | Low HDL and inflammatory pathways | rs241437 | TAP2 | Laurila et al. (43) | |
| rs9272143 | HLA-DRB1,HLA-DQA1 | ||||
| Mitochondrial Genome | Blood | Hypertension | m.8701A>G | MT-ATP6 | Zhu et al. (44) |
| CAD | Haplogroup T | Kofler et al. (45) | |||
| m.16189T>C | Mueller et al. (46) | ||||
| m.15927G>A | Jia et al. (47) |