Figure 1.

Vision for systemic chemotherapy. Following diagnosis and staging of a cancer, a patient is evaluated clinically with a panel of imaging tests and bloodwork. These data are used to quantify various tumor properties, drug pharmacokinetics, and off-target toxicities to parameterize a mathematical model of treatment response. The model is leveraged to identify optimal treatment plans. This process is repeated throughout the course of treatment to yield treatment plans that co-evolve with the patient’s tumor.