Table 3.
Features of virulent and avirulent in mice Klebsiella pneumoniae strains (n = 38).
| Strain | Year | Source | String test | К-type | ST | Resistance to antibacterials: number groups (functional classes) | Beta-lactamase genes | Virulence genes arraya | LD50, CFU |
|---|---|---|---|---|---|---|---|---|---|
| KPM9b | 2011 | Water | + | K20 | 1544 | 1 (BLA) | SHV-1 | 6 | 10 |
| KPS73 | 2016 | Lung | + | K1 | 23 | 1 (BLA) | SHV-1 | 7 | 44 |
| KPB1802K | 2013 | Trachea | + | K1 | 23 | 1 (BLA) | SHV-190 | 7 | 86 |
| KPI1683 | 2014 | Trachea | + | K1 | 23 | 2 (BLA NIT) | SHV-1 | 7 | 26 |
| KPI261 | 2014 | Trachea | + | K1 | 23 | 3 (BLA AMI NIT) | SHV-1, CTX-M-15 | 7 | 16 |
| KPB1493-1 | 2013 | Trachea | + | K1 | 23 | 6 (BLA TET QNL AMI SUL NIT) | SHV-11, TEM-1, CTX-M-15 | 7 | 4 × 102 |
| KPB463K-13 | 2013 | Trachea | + | K1 | 23 | 6 (BLA QNL AMI SUL NIT PHO) | SHV-11, TEM-1, CTX-M-15, OXA-48 | 7 | 1 × 104 |
| KPB475-14 | 2014 | Urine | + | K1 | 23 | 7 (BLA TET QNL CHL AMI SUL NIT) | SHV-11, TEM-1, CTX-M-15, OXA-48 | 7 | 1 × 103 |
| KPB594-14 | 2014 | Wound | + | K1 | 23 | 7 (BLA TET QNL CHL AMI SUL NIT) | SHV-11, TEM-1, CTX-M-15, OXA-48 | 7 | 3 × 103 |
| KPB1103-14 | 2014 | Urine | + | K1 | 23 | 7 (BLA TET QNL CHL AMI SUL NIT) | SHV-190, TEM-1, CTX-M-15, OXA-48 | 7 | 3 × 102 |
| KPB2580-14 | 2014 | Urine | + | K1 | 23 | 7 (BLA TET QNL CHL AMI SUL NIT) | SHV-11, TEM-1, CTX-M-15, OXA-48 | 7 | 17 |
| KPI1748 | 2014 | Trachea | + | K2 | 65 | 5 (BLA QNL CHL AMI SUL) | SHV-11 | 6 | 83 |
| KPB4010 | 2013 | Cerebrospinal fluid | + | K2 | 2280 | 3 (BLA TET NIT) | SHV-11 | 5a | 25 |
| KPI1627 | 2014 | Trachea | + | K2 | 86 | 2 (BLA NIT) | SHV-11 | 5a | 14 |
| KPI6208 | 2014 | Trachea | + | K2 | 86 | 3 (BLA TET NIT) | SHV-11 | 5a | 40 |
| KPB492-16 | 2016 | Wound | + | K2 | 86 | 1 (BLA) | SHV-11 | 5a | 1 × 103 |
| KPB463-16 | 2016 | Trachea | + | K2 | 86 | 1 (BLA) | SHV-11 | 5a | 1 × 103 |
| KPI3014 | 2014 | Trachea | + | K2 | 2174 | 6 (BLA TET QNL CHL AMI NIT) | SHV-11, TEM-1 | 5d | 1 × 104 |
| KPB550 | 2013 | Urine | + | K57 | 218 | 5 (BLA QNL PHO NIT SUL) | SHV-11, TEM-1, CTX-M-15, OXA-48 | 5b | 2 × 103 |
| KPB584 | 2013 | Urine | − | K57 | 218 | 4 (BLA SUL NIT PHO) | SHV-11, TEM-1, CTX-M-15, OXA-48 | 5b | >106 |
| KPB500 | 2013 | Trachea | + | K57 | 218 | 5 (BLA QNL SUL NIT PHO) | SHV-11, TEM-1, CTX-M-15, OXA-244 | 4b | >106 |
| KPB811K | 2013 | Cerebrospinal fluid | + | K57 | 218 | 5 (BLA QNL SUL NIT PHO) | SHV-11, TEM-1, CTX-M-15, OXA-244 | 4b | >106 |
| KPB757K | 2013 | Urine | + | K57 | 218 | 8 (BLA TET QNL CHL AMK SUL NIT PHO) | SHV-11, TEM-1, CTX-M-15, OXA-244 | 4b | >106 |
| KPB612-1 | 2013 | Trachea | + | K57 | 218 | 7 (BLA QNL AMI SUL PHO NIT CST) | SHV-11, TEM-1, CTX-M-15, OXA-48 | 4b | >106 |
| KPB690-14K | 2014 | Urine | − | K57 | 218 | 5 (BLA QNL CHL AMI NIT) | SHV-11, CTX-M-15, OXA-48 | 2b | >106 |
| KPB542-15 | 2015 | Urine | − | K57 | 23 | 7 (BLA QNL CHL AMI SUL NIT PHO) | SHV-11, CTX-M-15 | 3b | >106 |
| KPI112 | 2014 | Trachea | − | K57 | 23 | 4 (BLA QNL AMI SUL) | SHV-11, TEM-1, CTX-M-55 | 5c | >106 |
| KPB1493-2 | 2013 | Trachea | − | K62 | 48 | 4 (BLA CHL AMI NIT) | SHV-11, CTX-M-15 | 3a | >106 |
| KPB420-14 | 2014 | Urine | − | K62 | 48 | 7 (BLA TET QNL CHL AMI SUL NIT) | SHV-11, CTX-M-15 | 2a | >106 |
| KPB1224 | 2012 | Trachea | − | K47 | 395 | 6 (BLA TET QNL CHL AMI SUL) | SHV-11, TEM-1, CTX-M-15, OXA-48 | 4a | >106 |
| KPB1667 | 2013 | Urine | − | K47 | 395 | 6 (BLA QNL CHL AMI SUL NIT) | SHV-11, TEM-1, CTX-M-15, OXA-48 | 4a | >106 |
| KPB958-14 | 2014 | Urine | − | K14 | 147 | 7 (BLA TET QNL CHL AMI SUL NIT) | SHV-11, CTX-M-15, OXA-48 | 4a | >106 |
| KPB417-16 | 2016 | Trachea | − | K14 | 147 | 4 (BLA QNL AMI NIT) | SHV-11, TEM-1, CTX-M-15, OXA-48, NDM-1 | 3a | >106 |
| KPB941-14 | 2014 | Trachea | − | K27 | 833 | 7 (BLA TET QNL CHL AMI SUL NIT) | SHV-11, TEM-1, OXA-48 | 2b | >106 |
| KPB591-15 | 2015 | Cerebrospinal fluid | − | K28 | 20 | 2 (BLA NIT) | SHV-11, OXA-48 | 3a | >106 |
| KPB54-14 | 2014 | Urine | − | K60 | NI | 7 (BLA TET QNL CHL AMK SUL NIT) | SHV-11, TEM-1, CTX-M-15 | 4a | >106 |
| KPB944-14 | 2014 | Urine | − | wzi420c | 147 | 6 (BLA TET QNL CHL AMI NIT) | SHV-11, CTX-M-15, OXA-48 | 3a | >106 |
| KPB711-14 | 2014 | Wound | − | wzi420c | 147 | 6 (BLA TET QNL CHL AMI NIT) | SHV-11, CTX-M-15, OXA-48 | 0 | >106 |
a
The designations correspond to those presented in Table 2.
b
Reference strain for virulence in mice; ST – sequence type; NI – non identified.
c
Gene allele wzi420 is not associated with any known K-serotype in the Pasteur Institute Database; BLA – beta-lactams; TET – tetracyclines; QNL – quinolones; CHL – chloramphenicol; AMK – aminoglycosides; SUL – sulfonamides.