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TcdA and TcdB induce TPL2 activation in human colon tissue. Human colonic tissues (mixture of 3 samples) were exposed to TcdA or TcdB at 200 ng/ml for the indicated times. Tissues were lysed for 30 min and were centrifuged, and supernatants were used for Western blot analysis. Asterisks indicate significant differences (*, P < 0.01) from expression in the control.
