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TPL2-KO mice are more resistant to C. difficile infection than wild-type mice. TPL2-KO or TPL2-floxed (Flox) mice (n, 10 per group) were challenged with 106 C. difficile UK1 spores after treatment with a mixture of antibiotics. Mice were monitored for survival (P, <0.05 for the difference between the two groups) (A), weight changes (P, <0.0001 for the difference between the two groups) (B), and the percentage with diarrhea in the 7-day monitoring period (C).
