FIG 5.

(A) Genome fragments of igaB1 that contain the change between the first and final isolates of persistent NTHi strains during persistent infection in COPD patients. (B) Schematic representing the igaB1 gene (top) and functional domains (bottom). Arrows, the location in the open reading frame of the genomic changes shown in panel A; S, 25-amino-acid signal sequence; Protease, secreted IgA1 protease domain; P, short conserved peptide; Alpha protein, alpha protein; Beta-core, beta-barrel component of the type V secretion system.