Table 5.
Subgroup analyses for the outcome of overall survival
| Subgroups | No. of studies | HR (95% CI) | I2 (P value) |
|---|---|---|---|
| Population | |||
| Adult | 4 | 1.15 (0.86–1.53) | 0 (0.73) |
| Children | 3 | 2.40 (1.49–3.89) | 37.7% (0.20) |
| Mixed adult and children | 3 | 3.06 (1.98–4.70) | 32.1% (0.23) |
| Design | |||
| Prospective | 6 | 1.68 (1.02–2.77) | 60.1% (0.03) |
| Retrospective | 4 | 2.37 (1.55–3.63) | 64.8% (0.04) |
| Region | |||
| Europe | 5 | 2.05 (1.10–3.80) | 83.0% (< 0.01) |
| USA | 3 | 2.10 (1.50–2.94) | 1.8% (0.36) |
| Asia | 2 | 1.89 (0.99–3.62) | 0 (0.32) |
| Detection method | |||
| PCR | 6 | 1.65 (1.07–2.55) | 61.5% (0.02) |
| FC | 4 | 2.53 (1.58–4.04) | 58.1% (0.07) |
| Adjustment | |||
| Adjusted | 4 | 2.58 (1.27–5.26) | 71.1% (0.02) |
| Crude | 6 | 1.70 (1.18–2.44) | 58.7% (0.03) |