Table 2.
Frequencies of candidate gene loci subjected to subsequent validation
| Gene | rsID | Genotype | No. of patients (%) (n=185) |
|---|---|---|---|
| NUDT15 | rs116855232 | CC | 142 (77.6) |
| CT | 37 (20.2) | ||
| TT | 4 (2.2) | ||
| APEX1 | rs2307486 | AA | 155 (85.2) |
| AG | 26 (14.3) | ||
| GG | 1 (0.5) | ||
| ABCC4 | rs2274407 | GG | 116 (62.7) |
| GT | 62 (33.5) | ||
| TT | 7 (3.8) | ||
| rs3765534 | CC | 156 (85.2) | |
| CT | 24 (13.1) | ||
| TT | 3 (1.6) | ||
| rs11568658 | CC | 138 (75.0) | |
| CA | 41 (22.3) | ||
| AA | 5 (2.7) | ||
| CYP4F2 | rs2108622 | CC | 81 (44.0) |
| CT | 77 (41.8) | ||
| TT | 26 (14.1) | ||
| CYP1A1 | rs4646422 | CC | 125 (68.7) |
| CT | 51 (28.0) | ||
| TT | 6 (3.3) | ||
| SLCO1B1 | rs11045879 | TT | 74 (40.7) |
| TC | 74 (40.7) | ||
| CC | 34 (18.7) | ||
| rs4149056 | TT | 129 (70.5) | |
| TC | 51 (27.9) | ||
| CC | 3 (1.6) | ||
| ITPA | rs1127354 | CC | 131 (71.6) |
| CA | 47 (25.7) | ||
| AA | 5 (2.7) | ||
| rs7270101 | AA | 185 (100) | |
| MTHFR | rs1801131 | TT | 128 (69.2) |
| TG | 54 (29.2) | ||
| GG | 3 (1.6) | ||
| rs1801133 | GG | 61 (33.5) | |
| GA | 92 (50.5) | ||
| AA | 29 (15.9) | ||
| rs1901133 | GG | 84 (45.9) | |
| GA | 87 (47.5) | ||
| AA | 12 (6.6) | ||
| GRIA1 | rs4958351 | GG | 178 (96.2) |
| AG | 7 (3.8) | ||
| MOCOS | rs594445 | CC | 92 (49.7) |
| AC | 79 (42.7) | ||
| AA | 14 (7.6) | ||
| PACSIN2 | rs2413739 | CC | 155 (85.2) |
| CT | 27 (14.8) | ||
| TPMT | *1/*1 | 178 (96.2) | |
| *1/*3C | 7 (3.8) |