Table 3.
Genotypes associated with mercaptopurine-related neutropenia (ANC < 500/μL, n=179)
| Neutropenia | Allelic frequency |
Genotype (Dominant model) |
CATT p-value | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C | T | χ2 p-value | Fisher p-value | OR (95% CI) | CC | CT | TT | χ2 p-value | Fisher p-value | OR (95% CI) | ||||
| ABCC4 rs3765534 | Total (n=179) | Yes | 213 | 27 | 0.01 | 0.004 | 4.84 (1.44-25.48) | 96 | 21 | 3 | 0.016 | 0.008 | 4.64 (1.32-25.12) | 0.02 |
| No | 115 | 3 | 56 | 3 | 0 | |||||||||
| No NUDT15 rs116855232 (n=140) | Yes | 160 | 20 | 0.01 | 0.005 | 6.1 (1.43-54.9) | 71 | 18 | 1 | 0.014 | 0.006 | 6.36 (1.43-58.73) | 0.02 | |
| No | 98 | 2 | 48 | 2 | 0 | |||||||||
| Early-onset Neutropenia | A | G | χ2 p-value | Fisher p-value | OR (95% CI) | AA | AG | GG | χ2 p-value | Fisher p-value | OR (95% CI) | CATT p-value | ||
| APEX1 rs2307486 | Total (n=179) | Yes | 24 | 6 | 0.03 | 0.02 | 3.44 (1.04-9.89) | 10 | 4 | 1 | 0.09 | 0.06 | 3.18 (0.78-11.43) | 0.003 |
| No | 304 | 22 | 141 | 22 | 0 | |||||||||
ANC, absolute neutrophil count; OR, odds ratio; CI, confidence interval; CATT, Cochran-Armitage trend test.